The common outcome of interaction between solid tumors and the peripheral nervous system is neuropathic pain and possible extension of the tumor by means of perineural infiltration. This is not the case with melanoma. There are intra- tumor neural destruction and peritumoral attempted nerve repair. Axonal glial support cells are responsible for nerve repair.

In the peripheral nervous system, the Schwann has this role. It has been found that melanoma cells can redirect Schwann cell nerve damage repair programming to enhance invasiveness.

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